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Dim for males11/18/2023 Is DIM compatible with conventional therapy for cancer? Some studies suggest that, not only does it not interfere, but instead may protect normal tissue from the harmful effects of radiation while reinforcing cancer cell destruction. In addition to its hormone-modulating effects, DIM has been found to exert direct anti-cancer effects via a variety of mechanisms: It may promote DNA repair accelerate the death of cancer cells by restoring apoptosis (programmed cell death) it stimulates the activity of natural killer (NK) cells, the immune system’s surveillance against cancer and some studies suggests it has anti-angiogenesis effects, depriving growing cancers of their blood supply. Thus, DIM’s application to hormone-dependent cancers (breast and uterine in women, prostate in men), as well as to the condition of “ estrogen dominance”, wherein high estrogen levels promote symptoms like breast pain, fibrocystic breasts, uterine fibroids, endometriosis, PMS, bloating, anxiety, fat accumulation, and heavy menstruation.īecause DIM combats excess estrogen in females, it might help as a diet aid for women who struggle with a pear-shaped fat distribution.Īnother theoretical benefit of DIM may be to offset the potential risks of hormone-dependent cancers in patients taking hormone replacement therapy with estrogen or testosterone. In the prostate, DIM has been found to antagonize the effects of dihydrotestosterone (DHT), an excess of which is associated with risk of enlarged prostate and prostate cancer. DIM has also been shown to favorably alter the ratios of “good” to “bad” estrogen. Studies suggest it protects the body from xenoestrogens, compounds that mimic and intensify the effects of estrogen. To obtain the benefits of DIM contained in just two capsules per day, it is estimated that the average person would have to consume two pounds of raw cabbage family vegetables per day, an intake that might court the danger of thyroid suppression.ĭIM possesses hormone-modulating effects. DIM is thought not to have goitrogenic properties. These compounds compete with iodine for binding in the thyroid, potentially contributing to hypothyroidism. However, heat treatment, particularly boiling and microwaving, degrades myrosinase, the plant compound responsible for bio-transformation of glucobrassicans into useful molecules like DIM and sulforaphane.Īn advantage of supplementation with DIM over consumption of large amounts of raw cruciferous vegetables is avoidance of goitrogenic isothiocyanates. Brussel Sprouts, Garden Cress, Mustard Greens, Turnip, and Kale are rich sources of glucobrassicans, the mother compounds of beneficial glucosinolates like indole-3-carbinol, which is metabolized into DIM. It is naturally obtained via dietary consumption of cruciferous vegetables. This week, I’d like to talk to you about DIM.ĭiindolylmethane (DIM) is a versatile nutraceutical for which I find many uses in my practice. Serum testosterone enclomiphene secondary hypogonadism selective estrogen receptor modulator spermatogenesis topical testosterone.Every now and then, I like to highlight a particular supplement that my audience may not be aware of, and go in-depth about its uses, benefits, and potential drawbacks. This article reviews the difficulties associated with the FDA approval of a new molecular entity related to the treatment of hypogonadism. Initial studies demonstrated that enclomiphene maintains the androgenic benefit of clomiphene citrate without the undesirable effects attributable to zuclomiphene. Expert opinion: Enclomiphene has been shown to increase testosterone levels while stimulating FSH and LH production. The purpose of this drug profile is to examine the available literature on the trans-isomer enclomiphene. Zuclomiphene contributes little to the intended outcomes. The literature has suggested that most of the beneficial effects of clomiphene are due to the trans-isomer enclomiphene. Clomiphene citrate exists as a mixture of both the cis-isomer (zuclomiphene) and the trans-isomer (enclomiphene). Areas covered: The SERM, clomiphene citrate, which is approved by the FDA for the treatment of ovarian dysfunction, has been shown to have beneficial effects on male hypogonadism. This has lead to the use of alternative therapies such as selective estrogen receptor modulators (SERMs) that aim to correct hypogonadism without reducing fertility. One of the adverse effects of testosterone is its suppression of fertility. Treatments such as exogenous testosterone have become very popular. Hypogonadism is an important issue among the male population.
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